koumine
- CAS NO.：1358-76-5
- Empirical Formula: C20H22N2O
- Molecular Weight: 306.4
- MDL number: MFCD11111448
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-05 14:33:18
What is koumine?
Description
The Chinese drug 'Kou-wen', said to be derived from Gelsemium elegans Benth., is stated to contain this alkaloid which forms rhombic prisms from Me2 CO. It has [α]23D - 265° (EtOH) and forms a crystalline hydrochloride, m.p. 255°C (dec.) and a hydrobromide, m.p. 269°C (dec.).
Occurrence
Koumine is an alkaloid isolated from Gelsemium elegans Benth.
The Uses of koumine
Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages.
References
Chou, Pak, Hou., Chin. 1. Physiol., 5, 345 (1931)
Chou, Wang, Chen., ibid, 8,40 (1934)
Chi, Kao, Huang., 1. Amer. Chem. Soc., 60, 1723 (1938)
Properties of koumine
| Melting point: | 168℃ |
| Boiling point: | 436.5±45.0 °C(Predicted) |
| Density | 1.42 |
| storage temp. | 2-8°C |
| solubility | DMSO : 31.25 mg/mL (101.99 mM; Need ultrasonic) |
| form | powder |
| pka | 8.67±0.40(Predicted) |
| color | Yellow-brown |
Safety information for koumine
Computed Descriptors for koumine
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