(Dichloromethylene)dimethylammonium chloride
Synonym(s):(Dichloromethylene)dimethylammonium chloride;Phosgeniminium chloride;Vilsmeier reagent
- CAS NO.：33842-02-3
- Empirical Formula: C3H6Cl2N.Cl
- Molecular Weight: 162.45
- MDL number: MFCD00011870
- EINECS: 251-695-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:51:13
What is (Dichloromethylene)dimethylammonium chloride?
Chemical properties
light yellow crystalline powder
The Uses of (Dichloromethylene)dimethylammonium chloride
Chlorinating agent; introduces amide chloride groups into activated substrates. Building block in organic synthesis.
The Uses of (Dichloromethylene)dimethylammonium chloride
Dichloromethylene-dimethyliminium Chloride is a useful chemical reagent. It has been used in the synthesis of 12-deoxychlorovulone II analogs via chloride nucleophilic substitution reaction catalyzed by Viehe''s salt.
The Uses of (Dichloromethylene)dimethylammonium chloride
Dichloromethylene-dimethyliminium chloride was used as reagent in the synthesis of selenourea and (R)-2-(2-chloroethyl)pyrrolidine-1-carboxylic acid ethyl ester. It was used for introducing amide chloride group into activated substrates.
General Description
Dichloromethylene-dimethyliminium chloride (Vilsmeier reagent) reacts with o-acetaminophenols under Meth-Cohn conditions to yield 2-formylpyrido[2,1-b]benzoxazoles.
Properties of (Dichloromethylene)dimethylammonium chloride
| Melting point: | 183-187 °C (dec.) (lit.) |
| Boiling point: | 267.81°C (rough estimate) |
| Density | 1.6902 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | 2-8°C |
| solubility | slightly sol. in Chloroform |
| form | Crystalline Powder |
| color | Light yellow |
| Water Solubility | hydrolysis |
| Sensitive | Moisture Sensitive |
| Merck | 14,9977 |
| BRN | 4157987 |
| CAS DataBase Reference | 33842-02-3(CAS DataBase Reference) |
Safety information for (Dichloromethylene)dimethylammonium chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H290:Corrosive to Metals H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P390:Absorb spillage to prevent material damage. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P406:Store in corrosive resistant/… container with a resistant inner liner. P501:Dispose of contents/container to..… |
Computed Descriptors for (Dichloromethylene)dimethylammonium chloride
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