DELTA12-PROSTAGLANDIN J2
- CAS NO.：87893-54-7
- Empirical Formula: C20H30O4
- Molecular Weight: 334.45
- MDL number: MFCD00065805
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 22:51:18
What is DELTA12-PROSTAGLANDIN J2?
Description
Δ12-
The Uses of DELTA12-PROSTAGLANDIN J2
delta12-PGJ2 (delta12-Prostaglandin J2) is a decomposition product of PGD2 showing potent antiviral and anti-proliferative activity.
The Uses of DELTA12-PROSTAGLANDIN J2
Δ12-PGJ2 is a decomposition product of PGD2 in aqueous media in the presence of albumin. It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 μg/ml. Δ12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng. It is also a moderately potent PPARγ ligand.
What are the applications of Application
Δ12-PGJ2 (Δ12-Prostaglandin J2) is a decomposition product of PGD2 showing potent antiviral and anti-proliferative activity
Definition
ChEBI: 13,14-dihydro-Delta(12)-prostaglandin J2 is a member of the class of prostaglandins J that is prosta-5,9,12-trien-1-oic acid carrying oxo and hydsroxy substituents at positions 11 and 15 respectively (the 5Z,12E,15S-stereoisomer). It has a role as an antineoplastic agent and an antiviral agent. It is a prostaglandins J and a secondary alcohol. It is functionally related to a prostaglandin J2. It is a conjugate acid of a 13,14-dihydro-Delta(12)-prostaglandin J2(1-).
Properties of DELTA12-PROSTAGLANDIN J2
| Boiling point: | 531.2±50.0 °C(Predicted) |
| Density | 1.111±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-d12, |
| form | Liquid |
| pka | 4.75±0.10(Predicted) |
| color | Colorless to light yellow |
Safety information for DELTA12-PROSTAGLANDIN J2
Computed Descriptors for DELTA12-PROSTAGLANDIN J2
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