DELTA12-PROSTAGLANDIN J2

CAS NO.：87893-54-7
Empirical Formula: C20H30O4
Molecular Weight: 334.45
MDL number: MFCD00065805
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 22:51:18

What is DELTA12-PROSTAGLANDIN J2?

Description

Δ¹²-PGJ₂ is a decomposition product of PGD₂ in aqueous media in the presence of albumin. It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC₅₀ value of 0.7 μg/ml. Δ¹²-PGJ₂ is present in normal human urine with a 24 hour excretion rate of 50-150 ng. It is also a moderately potent PPARγ ligand.

The Uses of DELTA12-PROSTAGLANDIN J2

delta12-PGJ2 (delta12-Prostaglandin J2) is a decomposition product of PGD2 showing potent antiviral and anti-proliferative activity.

The Uses of DELTA12-PROSTAGLANDIN J2

Δ12-PGJ2 is a decomposition product of PGD2 in aqueous media in the presence of albumin. It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 μg/ml. Δ12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng. It is also a moderately potent PPARγ ligand.

What are the applications of Application

Δ12-PGJ2 (Δ12-Prostaglandin J2) is a decomposition product of PGD2 showing potent antiviral and anti-proliferative activity

Definition

ChEBI: 13,14-dihydro-Delta(12)-prostaglandin J2 is a member of the class of prostaglandins J that is prosta-5,9,12-trien-1-oic acid carrying oxo and hydsroxy substituents at positions 11 and 15 respectively (the 5Z,12E,15S-stereoisomer). It has a role as an antineoplastic agent and an antiviral agent. It is a prostaglandins J and a secondary alcohol. It is functionally related to a prostaglandin J2. It is a conjugate acid of a 13,14-dihydro-Delta(12)-prostaglandin J2(1-).

Properties of DELTA12-PROSTAGLANDIN J2

Boiling point:	531.2±50.0 °C(Predicted)
Density	1.111±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-d12,
form	Liquid
pka	4.75±0.10(Predicted)
color	Colorless to light yellow