DBCO-Acid

CAS NO.：1353016-70-2
Empirical Formula: C19H15NO3
Molecular Weight: 305.33
MDL number: MFCD28064336
SAFETY DATA SHEET (SDS)
Update Date: 2026-03-13 09:27:42

What is DBCO-Acid?

Description

DBCO-Acid is a non-activated building block and adds minimal spacer to modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize amine-containing molecules through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

The Uses of DBCO-Acid

DBCO-Acid is a reactant in the synthesis of high-generation polyester dendrimers. Also used in the preparation of modular, plasmin sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere systems for creating growth factor gradients in peripheral nerve regeneration.

General Description

Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne click chemistry reactions. This azadibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Properties of DBCO-Acid

Melting point:	118-125 °C
Boiling point:	622.0±55.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in dimethyl sulfoxide and dimethyl formamide.
pka	4.47±0.17(Predicted)
form	Solid
color	Off-white to Gray

Safety information for DBCO-Acid

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed.