D-Norleucine
Synonym(s):(R)-2-Aminocaproic acid;(R) -2-Aminohexanoic acid
- CAS NO.：327-56-0
- Empirical Formula: C6H13NO2
- Molecular Weight: 131.17
- MDL number: MFCD00008099
- EINECS: 206-320-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is D-Norleucine?
Chemical properties
white to off-white crystalline powder or flakes
The Uses of D-Norleucine
D-Norleucine is used for the synthesis of Thailandepsin B, a bicyclic depsipeptide histone deacetylase inhibitor.
Definition
ChEBI: D-norleucine is the D-enantiomer of 2-aminohexanoic acid. It is an enantiomer of a L-norleucine. It is a tautomer of a D-norleucine zwitterion.
Purification Methods
Crystallise norleucine from water or aqueous MeOH. [Huffman & Ingersoll J Am Chem Soc 73 3366 1951, Beilstein 4 III 1386, 4 IV 2628.]
Properties of D-Norleucine
| Melting point: | ≥300 °C |
| Boiling point: | 234.0±23.0 °C(Predicted) |
| alpha | [α]D20 -23.0～-25.0゜ (c=4, HCl) |
| Density | 1.1720 (estimate) |
| refractive index | -23 ° (C=4.5, 6mol/L HCl) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 2.55±0.24(Predicted) |
| color | White |
| Water Solubility | 15.75g/L(19 ºC) |
| Merck | 14,6706 |
| BRN | 1721749 |
| CAS DataBase Reference | 327-56-0(CAS DataBase Reference) |
Safety information for D-Norleucine
Computed Descriptors for D-Norleucine
| InChIKey | LRQKBLKVPFOOQJ-RXMQYKEDSA-N |
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