D-Ephedrine hydrochloride
Synonym(s):(1S,2R)-(+)-α-(1-Methylaminoethyl)benzyl alcohol hydrochloride;(1S,2R)-(+)-2-Methylamino-1-phenyl-1-propanol hydrochloride;D -α-(1-Methylaminoethyl)benzyl alcohol hydrochloride
- CAS NO.：24221-86-1
- Empirical Formula: C10H16ClNO
- Molecular Weight: 201.69
- MDL number: MFCD00064551
- EINECS: 246-090-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:52:17
What is D-Ephedrine hydrochloride?
Chemical properties
white crystalline powder
The Uses of D-Ephedrine hydrochloride
α- and β-Adrenergic agonist. Bronchodilator.
Safety Profile
A poison by intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also EPHEDRINE
Purification Methods
Recrystallise the hydrochloride from EtOH/Et2O. The free base crystallises from *C6H6 with m 40-41o (Skita et al. Chem Ber 66 974 1933]. [Beilstein 13 H 254, 13 II 375, 13 III 1721, 13 IV 1879.]
Properties of D-Ephedrine hydrochloride
| Melting point: | 218-220 °C(lit.) |
| alpha | 34.3 º (c=5, H2O) |
| Flash point: | 9℃ |
| storage temp. | Refrigerator |
| solubility | DMF: 10 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml |
| form | A crystalline solid |
| optical activity | [α]23/D +34.3°, c = 5 in H2O |
| BRN | 6118541 |
| CAS DataBase Reference | 24221-86-1(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenemethanol, .alpha.-[(1R)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (24221-86-1) |
Safety information for D-Ephedrine hydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for D-Ephedrine hydrochloride
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