CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P

The Uses of CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P

It is one of a series of AMPA modulators matergic AMPA receptors.

The Uses of CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

What are the applications of Application

CX546 is an AMPA receptor potentiator and GluR activator

General Description

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

Biological Activity

AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats.

Biochem/physiol Actions

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI)?in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

Storage

Store at +4°C