curvularin
Synonym(s):2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)-
- CAS NO.：10140-70-2
- Empirical Formula: C16H20O5
- Molecular Weight: 292.33
- MDL number: MFCD09752718
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-05 11:31:08
What is curvularin?
The Uses of curvularin
Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species, including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology.
The Uses of curvularin
Curvularin is a potent antifungal and mycotoxin that also inhibits NO production.
What are the applications of Application
Curvularin is a potent antifungal and mycotoxin that also inhibits NO production
Storage
+4°C
Properties of curvularin
| Melting point: | 206-206.5° |
| Boiling point: | 557.0±29.0 °C(Predicted) |
| alpha | D18 -36.3° (c = 3.8 in ethanol) |
| Density | 1.200±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble1mg/mL |
| form | powder |
| pka | 7.58±0.40(Predicted) |
| color | Off-white |
Safety information for curvularin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for curvularin
New Products
Cyclopentane-1,2-dione Isopropyl amine Hydrochloride 8-hydroxy-7-methoxy-2,6-dimethylisoquinolinium iodide 4-Chlorobutyronitrile (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Amino-4-methoxyben-zeneacetic acid 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 3-Aminophenylacetic acid 2-Bromo-5-iodopyridine Rifaximin EP Impurity-G N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity (R)-BoroLeu-(+)-Pinanediol-CF3COOH 1,4-bis(methylsulfonyl)butane 4-Cyano-N-Methacryloyl-3-Trifluoromethyl Aniline 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene 2-Chloro Benzylcyanide 3,4 Diethoxy Benzylcyanide 3,4 Dimethoxy BenzylcyanideRelated products of tetrahydrofuran
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