CLOFOCTOL

Synonym(s):2-(2,4-Dichlorobenzyl)-4-(1,1,3,3-tetramethylbutyl)phenol

CAS NO.：37693-01-9
Empirical Formula: C21H26Cl2O
Molecular Weight: 365.34
MDL number: MFCD00079014
EINECS: 253-632-6
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is CLOFOCTOL?

Originator

Octofene,Debat,France,1978

The Uses of CLOFOCTOL

Clofoctol is a bacteriostatic antibiotic used against gram-positive bacteria.

The Uses of CLOFOCTOL

antibacterial

Definition

ChEBI: 2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol is a diarylmethane.

Manufacturing Process

The following were introduced into a 1 liter flask provided with a reflux condenser: 206 g (1 mol) of p-(1,1,3,3-tetramethylbutyl)-phenol, 147 g (0.75 mol) of 2,4-dichlorobenzyl chloride, 27 g (0.2 mol) of pure melted zinc chloride, and 750 ml of anhydrous chloroform.
The mixture was heated to reflux for 24 hours. The chloroformic reaction mixture was washed with water, and then dried over anhydrous sodium sulfate. The chloroform was evaporated off and the oil obtained was fractionally distilled under a pressure of 0.2 mm Hg. The fraction distilling at 140°C to 160°C, being the desired product indicated above, was collected and crystallized. Yield: 94 g (32% of theory); MP 78°C (after recrystallization in petroleum ether).

Therapeutic Function

Antiinfective, Bacteriostatic

Properties of CLOFOCTOL

Melting point:	78°
Boiling point:	447.7±40.0 °C(Predicted)
Density	1.127±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO:100.0(Max Conc. mg/mL);273.72(Max Conc. mM)
form	Solid
pka	10.09±0.45(Predicted)
form	neat
color	White to off-white

Safety information for CLOFOCTOL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.