CIS-ACONITIC ANHYDRIDE
Synonym(s):cis-Propene-1,2,3-tricarboxylic anhydride
- CAS NO.：6318-55-4
- Empirical Formula: C6H4O5
- Molecular Weight: 156.09
- MDL number: MFCD00005524
- EINECS: 228-663-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:34
What is CIS-ACONITIC ANHYDRIDE?
The Uses of CIS-ACONITIC ANHYDRIDE
cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).
Purification Methods
Reflux it in xylene (7.5 parts) for 1hour, then evaporate and recrystallise the residue from *C6H6. Alternatively, reflux it in Ac2O, evaporate and recrystallise from *C6H6. It is sensitive to moisture. [IR: Groth & Dahlén Acta Chem Scand 21 291 1967, Malachowski & Maslowski Chem Ber 61 2523 1928, NMR: Gawron & Mahajan Biochemistry 5 2335 1966.] [Beilstein 18/8 V 530.]
Properties of CIS-ACONITIC ANHYDRIDE
| Melting point: | 75-78 °C (lit.) |
| Boiling point: | 397.8±25.0 °C(Predicted) |
| Density | 1.621±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 3?+-.0.10(Predicted) |
| Sensitive | Moisture Sensitive |
| BRN | 127575 |
| CAS DataBase Reference | 6318-55-4(CAS DataBase Reference) |
| EPA Substance Registry System | 3-Furanacetic acid, 2,5-dihydro-2,5-dioxo- (6318-55-4) |
Safety information for CIS-ACONITIC ANHYDRIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CIS-ACONITIC ANHYDRIDE
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