Methyl 4-oxobutanoate
- CAS NO.：13865-19-5
- Empirical Formula: C5H8O3
- Molecular Weight: 116.12
- MDL number: MFCD00082185
- EINECS: 237-611-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:07
What is Methyl 4-oxobutanoate?
Description
Methyl-4-oxobutyrate is a kind of oxobutyrate derivative. It is an important industrial intermediate. It, together with its methanol addition products such as methyl 4,4-dimethoxybutyrate and gamma- methoxy-gamma-butyrolactone are useful intermediates during the preparation of some important industrial compounds such as gamma- butyrolactone, 1,4-butanediol and glutamate. It is also useful as a model substrate during exploring the asymmetric henry reaction since it can assemble a stereodefined lactam with high efficiency and enantiomeric purity.
The Uses of Methyl 4-oxobutanoate
Methyl 4-oxobutanoate may be used as a starting material to synthesize (-)-deoxoprosophylline, a piperidine alkaloid with therapeutic potential.
What are the applications of Application
Methyl 4-oxobutanoate is a simple aldehyde methyl ester compound
References
Gresham, William F, R. E. Brooks, and W. M. Bruner. "Preparation of methyl 4-oxobutyrate." US2549454. 1951.
Murib, Jawad H, and W. D. Baugh. "Process for the preparation of methyl 4-oxobutyrate and its methanol addition products." US, US5072005. 1991.
https://www.scbt.com/scbt/product/methyl-4-oxobutanoate-13865-19-5
Properties of Methyl 4-oxobutanoate
| Boiling point: | 187-188 °C(lit.) |
| Density | 1.109 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 187 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| color | Colourless |
Safety information for Methyl 4-oxobutanoate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Methyl 4-oxobutanoate
| InChIKey | DLZVZNAPRCRXEG-UHFFFAOYSA-N |
New Products
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![2-[(2,3-Dichlorophenyl)methylene]-3-oxobutanoic acid methyl ester](https://img.chemicalbook.in/CAS/GIF/74073-22-6.gif)
![4-[[(2S)-2-Methyl-3-phenylpropyl]thio]-4-oxobutanoic acid methyl ester](https://img.chemicalbook.in/CAS/20200119/GIF/CB02335425.gif)
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