Chlorodifluoroacetic acid ethyl ester
- CAS NO.：383-62-0
- Empirical Formula: C4H5ClF2O2
- Molecular Weight: 158.53
- MDL number: MFCD00013662
- EINECS: 206-850-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:13
What is Chlorodifluoroacetic acid ethyl ester?
Chemical properties
clear colorless liquid
The Uses of Chlorodifluoroacetic acid ethyl ester
Ethyl chlorodifluoroacetate (ECDFA) may be used as a starting reagent in the synthesis of 3-gem-difluoro-2-ethoxy allylic alcohols.
General Description
Ethyl chlorodifluoroacetate (ECDFA) undergoes Reformatskii reaction with various aldehydes in DMF. It reacts with phenylacetylene to afford ethyl α,α?difluoro-4-phenyl-3-butenoates.
Properties of Chlorodifluoroacetic acid ethyl ester
| Boiling point: | 96-97.5 °C (lit.) |
| Density | 1.252 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 65 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Sparingly) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 1.252 |
| Sensitive | Moisture Sensitive |
| BRN | 1761413 |
| CAS DataBase Reference | 383-62-0(CAS DataBase Reference) |
| EPA Substance Registry System | Acetic acid, chlorodifluoro-, ethyl ester (383-62-0) |
Safety information for Chlorodifluoroacetic acid ethyl ester
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H225:Flammable liquids H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Chlorodifluoroacetic acid ethyl ester
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