CGS 15943
Synonym(s):9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
- CAS NO.：104615-18-1
- Empirical Formula: C13H8ClN5O
- Molecular Weight: 285.69
- MDL number: MFCD01529897
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-07 19:09:50
What is CGS 15943?
The Uses of CGS 15943
Potent adenosine receptor antagonist
What are the applications of Application
CGS 15943 is a potent Adenosine A Receptor antagonist
Definition
ChEBI: A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosi e A2A receptors.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 27, p. 1549, 1990 DOI: 10.1002/jhet.5570270605
Biological Activity
Potent adenosine receptor antagonist (K i values are 3.5, 4.2, 16 and 51 nM for human A 1 , A 2A , A 2B and A 3 receptors respectively). Orally active in vivo .
Biochem/physiol Actions
CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity.
Storage
Store at RT
Properties of CGS 15943
| Melting point: | 278-279 °C |
| Density | 1.72±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: >16 mg/mL |
| form | solid |
| pka | 1.23±0.30(Predicted) |
| color | white |
Safety information for CGS 15943
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CGS 15943
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