CGS 15943

Synonym(s):9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

CAS NO.：104615-18-1
Empirical Formula: C13H8ClN5O
Molecular Weight: 285.69
MDL number: MFCD01529897
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is CGS 15943?

The Uses of CGS 15943

Potent adenosine receptor antagonist

What are the applications of Application

CGS 15943 is a potent Adenosine A Receptor antagonist

Definition

ChEBI: A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosi e A2A receptors.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 27, p. 1549, 1990 DOI: 10.1002/jhet.5570270605

Biological Activity

Potent adenosine receptor antagonist (K i values are 3.5, 4.2, 16 and 51 nM for human A 1 , A 2A , A 2B and A 3 receptors respectively). Orally active in vivo .

Biochem/physiol Actions

CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity.

Storage

Store at RT

Properties of CGS 15943

Melting point:	278-279 °C
Density	1.72±0.1 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: >16 mg/mL
form	solid
pka	1.23±0.30(Predicted)
color	white

Safety information for CGS 15943

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.