CGP 52432
Synonym(s):[3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)-phosphinic acid
- CAS NO.：139667-74-6
- Empirical Formula: C15H24Cl2NO4P
- Molecular Weight: 384.24
- MDL number: MFCD09878290
- EINECS: 000-000-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is CGP 52432?
The Uses of CGP 52432
CGP52432 has been used as a γ-aminobutyric acid B (GABAB) antagonist:
- to study its effects on the simulation of the onset of status epilepticus (SE) in mice
- for voltage-clamp recording in mice neurons
- to study its effects on the GABAB receptor-mediated neurotransmission in guinea pig hippocampus
What are the applications of Application
CGP 52432 is A selective and effective GABAB receptor antagonist
Definition
ChEBI: 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid is a dichlorobenzene.
Biological Activity
Potent, selective GABA B receptor antagonist (IC 50 = 85 nM).
Biochem/physiol Actions
CGP52432 participates in inhibiting the glycine overflow in the hippocampus.
Storage
+4°C (desiccate)
Properties of CGP 52432
| Boiling point: | 544.4±50.0 °C(Predicted) |
| Density | 1.258±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble1mg/mL, clear (warmed) |
| form | powder |
| pka | 2.26±0.50(Predicted) |
| color | white to beige |
| Water Solubility | Soluble in water (10mM, gentle warming) |
Safety information for CGP 52432
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CGP 52432
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