CGP 52432

Synonym(s):[3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)-phosphinic acid

CGP52432 has been used as a γ-aminobutyric acid B (GABA_B) antagonist:

to study its effects on the simulation of the onset of status epilepticus (SE) in mice
for voltage-clamp recording in mice neurons
to study its effects on the GABA_B receptor-mediated neurotransmission in guinea pig hippocampus

CGP 52432 is A selective and effective GABAB receptor antagonist

ChEBI: 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid is a dichlorobenzene.

Potent, selective GABA B receptor antagonist (IC 50 = 85 nM).

CGP52432 participates in inhibiting the glycine overflow in the hippocampus.

+4°C (desiccate)

Boiling point:	544.4±50.0 °C(Predicted)
Density	1.258±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H2O: soluble1mg/mL, clear (warmed)
form	powder
pka	2.26±0.50(Predicted)
color	white to beige
Water Solubility	Soluble in water (10mM, gentle warming)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.