Cefmetazole sodium

Chemical properties

White Solid

The Uses of Cefmetazole sodium

Cefmetazole sodium is used clinically in combination with Tanreqing for the treatment of Pulmonary infections like Senile Emphysema and other acute bacterial infections.

The Uses of Cefmetazole sodium

Semi-synthetic antibiotic derived from Cephamycin. Antibacterial

What are the applications of Application

Cefmetazole sodium salt is a cephalosporin antibiotic

Definition

ChEBI: An organic sodium salt that is the sodium salt of cefmetazole.

brand name

Zefazone (Pharmacia & Upjohn）.

Clinical Use

Cefmetazole (Zefazone) is a semisynthetic, third-generation,parenteral cephalosporin of the cephamycin group. Likeother cephamycins, the presence of the 7α-methoxyl groupconfers resistance to many β-lactamases. Cefmetazoleexhibits significantly higher potency against members ofthe Enterobacteriaceae family but lower activity againstBacteroides spp. than cefoxitin. It is highly active againstN. gonorrhoeae, including -lactamase–producing strains. Incommon with other cephamycins, cefmetazole is ineffectiveagainst indole-positive Proteus, Enterobacter, Providencia,Serratia, and Pseudomonas spp. Cefmetazole has the MTTmoiety associated with increased bleeding in certain highriskpatients. It has a plasma half-life of 1.1 hours.