Cefazolin
Synonym(s):Cefazolin;Cephazolin;CFZ
- CAS NO.:25953-19-9
- Empirical Formula: C14H14N8O4S3
- Molecular Weight: 454.51
- MDL number: MFCD00243010
- EINECS: 247-362-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-20 16:43:00
![Cefazolin Structural](https://img.chemicalbook.in/CAS/GIF/25953-19-9.gif)
What is Cefazolin?
Absorption
Not absorbed from GI tract. Must be administered parenterally. Peak serum concentrations attained 1-2 hours post intramuscular injection.
Description
Cefazolin has the natural acetyl side chain at C-3 replaced by a thio-linked thiadiazole ring. Although this group is an activating leaving group, the moiety is not subject to the inactivating host hydrolysis reaction that characterizes cephapirin. At C-7, it possesses a tetrazoylmethylene unit. Cefazolin is less irritating on injection than its cohort in this generation of drugs and has a longer half-life than cephapirin. Its dosing should be reduced in the presence of renal impairment. It is comparatively unstable and should be protected from heat and light.
The Uses of Cefazolin
Cefazolin is an antibacterial compound derived from 7-amino-cephalosporanic acid.
Background
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Indications
Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
What are the applications of Application
Cefazolin is a semisyntheti cephalosporin analogue
Pharmacokinetics
Cefazolin (also known as cefazoline or cephazolin) is a semi-synthetic first generation cephalosporin for parenteral administration. Cefazolin has broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Metabolism
Not metabolized.
Properties of Cefazolin
Melting point: | 198-200 C |
Density | 2.01±0.1 g/cm3(Predicted) |
storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
solubility | DMSO (Slightly), Methanol (Very Slightly, Heated) |
form | neat |
color | White to Off-White |
Safety information for Cefazolin
Signal word | Danger |
Pictogram(s) |
![]() Health Hazard GHS08 |
GHS Hazard Statements |
H317:Sensitisation, Skin H334:Sensitisation, respiratory |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
Computed Descriptors for Cefazolin
New Products
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