BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT

CAS NO.：87779-49-5
Empirical Formula: C30H37N7O6
Molecular Weight: 591.66
MDL number: MFCD02259608
SAFETY DATA SHEET (SDS)
Update Date: 2025-08-06 15:14:14

What is BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT?

Description

Bz-VGR-AMC (87779-49-5) may be used for measuring the trypsin-like activity of the 20S proteasome, in combination with Suc-LLVY-AMC (Cat.# 10-2971, for assaying its chymotrypsin-like activity) and Z-LLE-AMC, (for determining its PGPH activity). Fluorogenic substrate. Ex.: 380nm Em.: 460nm.

The Uses of BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT

Bz-Val-Gly-Arg-AMC is a bioactive compound used in assaying the degree of inhibition conferred by PS-341, a potent peptidylboronic acid with anticancer properties.

References

1) Gillardon?et al. (2007),?The 20S proteasome isolated from Alzheimer’s disease brain shows post-translational modifications but unchanged proteolytic activity; J. Neurochem.,?101?1483 2) Kim?et al. (2002),?Navigation inside a protease: substrate selection and product exit in tricorn protease from Thermoplasma acidophilum; J. Mol. Biol.,?324?1041 3) Dahlmann?et al. (2000),?Different proteasome subtypes in a single tissue exhibit different enzymatic properties; J. Mol. Biol.,?303?643 4) Lightcap?et al. (2000),?Proteasome inhibition measurements: clinical application; Clin. Chem.,?46?673

Properties of BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT

storage temp.	-15°C
solubility	Soluble in DMSO.
form	White powder.
color	White
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.