Butyl hydroxyacetate

Synonym(s):Butyl hydroxyacetate

CAS NO.：7397-62-8
Empirical Formula: C6H12O3
Molecular Weight: 132.16
MDL number: MFCD00042732
EINECS: 230-991-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:21:03

What is Butyl hydroxyacetate?

Chemical properties

Colorless Transparent Liquid. n-Butyl glycolate is a colorless liquid, which is miscible with most organic solvents. The solubility in water is limited to 8 wt % (20 C), although the compound itself may contain up to 25 wt % water.

The Uses of Butyl hydroxyacetate

Butyl glycolate may be used in the preparation of N-(α-hydroxyacetyl)-(S)-isoleucine.

Production Methods

n-Butyl glycolate is produced by treatment of sodium chloroacetate with nbutyl alcohol at 125 – 160℃, followed by vacuum distillation.

General Description

Butyl glycolate is a glycolic acid derivative.

Purification Methods

Dissolve in CHCl3 (EtOH-free), wash with 5% KHCO3 until effervescence ceases (if free acid is present), dry over CaCl2, filter, evaporate and distil through a short column. [B.hme & Opfer Z Anal Chem 139 255 1953, Filachione et al. J Am Chem Soc 73 5265 1951, Beilstein 3 IV 589.]

Properties of Butyl hydroxyacetate

Boiling point:	187-190 °C(lit.)
Density	1.019 g/mL at 20 °C(lit.)
vapor pressure	1.3hPa at 20℃
refractive index	n20/D 1.427
Flash point:	74 °C
storage temp.	2-8°C
pka	12.99±0.10(Predicted)
Water Solubility	46g/L at 20℃
BRN	1749477
CAS DataBase Reference	7397-62-8(CAS DataBase Reference)
NIST Chemistry Reference	Butyl glycolate(7397-62-8)
EPA Substance Registry System	Acetic acid, hydroxy-, butyl ester (7397-62-8)

Safety information for Butyl hydroxyacetate

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Health Hazard GHS08
GHS Hazard Statements	H318:Serious eye damage/eye irritation H361:Reproductive toxicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention.