Butedronic acid
- CAS NO.：51395-42-7
- Empirical Formula: C5H10O10P2
- Molecular Weight: 292.07
- MDL number: MFCD09837954
- EINECS: 403-070-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:39
What is Butedronic acid?
Originator
Butedronic acid,Bayer A.G.
Definition
ChEBI: Butedronic acid is a 1,1-bis(phosphonic acid).
Manufacturing Process
0.5 mole of methylene diphosphonic acid tetraethyl ester is heated for 6 h to
110°C with 0.5 mole of maleic acid diethyl ester in the presence of 25 ml of a
saturated sodium ethylate solution. The sodium ethylate is then neutralized
with acetic acid and the reaction mixture is quickly distilled invacuo in order to
avoid decomposition. The crude distillate is redistillated, the main fraction
accumulating in the range from 190-213°C at a pressure of 0.05 Torr, yield
50%.
The ester is hydrolyzed by boiling with concentrated hydrochloric acid. 1,1-
Diphosphonopropane-2,3-dicarboxylic acid crystallizes out after purification
with active carbon and concentration of the hydrolysis product, yield 100%.
Therapeutic Function
Diagnostic aid
Properties of Butedronic acid
| Melting point: | 149.5 °C |
| Boiling point: | 701.4±70.0 °C(Predicted) |
| Density | 2.095±0.06 g/cm3(Predicted) |
| pka | 0.38±0.10(Predicted) |
Safety information for Butedronic acid
Computed Descriptors for Butedronic acid
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
You may like
-
1122-58-3 99%View Details
1122-58-3 -
5-Methoxy-2-Mercapto Benzimidazole 99%View Details
37052-78-1 -
15128-52-6 99%View Details
15128-52-6 -
3,6-Dichloropyridazine 99%View Details
141-30-0 -
2-Chlorotrityl Chloride 99%View Details
42074-68-0 -
5-Bromo-2-chlorobenzoic acid 21739-92-4 99%View Details
21739-92-4 -
106-40-1 99%View Details
106-40-1 -
15128-52-6 1,2,3,9-Tetrahydro-4(H)-carbazol-4-one 99%View Details
15128-52-6