Butedronic acid
- CAS NO.：51395-42-7
- Empirical Formula: C5H10O10P2
- Molecular Weight: 292.07
- MDL number: MFCD09837954
- EINECS: 403-070-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:53:56
What is Butedronic acid?
Originator
Butedronic acid,Bayer A.G.
Definition
ChEBI: Butedronic acid is a 1,1-bis(phosphonic acid).
Manufacturing Process
0.5 mole of methylene diphosphonic acid tetraethyl ester is heated for 6 h to
110°C with 0.5 mole of maleic acid diethyl ester in the presence of 25 ml of a
saturated sodium ethylate solution. The sodium ethylate is then neutralized
with acetic acid and the reaction mixture is quickly distilled invacuo in order to
avoid decomposition. The crude distillate is redistillated, the main fraction
accumulating in the range from 190-213°C at a pressure of 0.05 Torr, yield
50%.
The ester is hydrolyzed by boiling with concentrated hydrochloric acid. 1,1-
Diphosphonopropane-2,3-dicarboxylic acid crystallizes out after purification
with active carbon and concentration of the hydrolysis product, yield 100%.
Therapeutic Function
Diagnostic aid
Properties of Butedronic acid
| Melting point: | 149.5 °C |
| Boiling point: | 701.4±70.0 °C(Predicted) |
| Density | 2.095±0.06 g/cm3(Predicted) |
| pka | 0.38±0.10(Predicted) |
Safety information for Butedronic acid
Computed Descriptors for Butedronic acid
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