Brodimoprim
- CAS NO.：56518-41-3
- Empirical Formula: C13H15BrN4O2
- Molecular Weight: 339.1878
- MDL number: MFCD00864849
- EINECS: 2602388
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-29 15:43:00
What is Brodimoprim?
Description
Brodimoprim, a dihydrofolate reductase inhibitor, was introduced for the treatment of common infections of upper respiratory tract such as sinusitis and exacerbation of chronic bronchitis. It has a broad spectrum of antimicrobial activities against most Gram-positive and -negative pathogens including some bacterial strains that are resistant to amoxicillin, a widely used antibiotic for the indicated infections. Brodimoprim also has a favorable pharmacokinetic profile exemplified by its long half-life and good tissue penetration.
Chemical properties
Off-White to Pale Yellow Solid
Originator
Helsinn (Switzerland)
The Uses of Brodimoprim
A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent.
Definition
ChEBI: An aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group.
brand name
Hyprim;Unitrim
Properties of Brodimoprim
| Melting point: | 225-228° |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Sparingly) |
| form | Solid |
| pka | 7.15(at 25℃) |
| color | White to Pale Yellow |
| Stability: | Light Sensitive |
Safety information for Brodimoprim
Computed Descriptors for Brodimoprim
New Products
2,6-Piperidinedione, 3-hydroxy-1-[(4-methoxyphenyl)methyl]- 3-(4-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione 4-Hydroxy-6-methyl-1-(4-methylphenyl)-2-naphthalenecarboxylic acid 2,3-Difluoro-6-methoxybenzyl Chloride KT-474 2-(6-(benzyloxy)-3,4-dihydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3-Oxocyclobutanecarboxylic acid 5-Bromo-2-iodo pyridine Benzofuran-6-carboxylic acid (BFA) 3-Bromo-2-Ethoxy-5-Nitropyridine 3,6-Dichloro-2-Methylpyridine 2-Amino-5-Bromo-3-IodopyridineRelated products of tetrahydrofuran
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