BEPHENIUM HYDROXYNAPHTHOATE
Synonym(s):Benzyldimethyl(2-phenoxyethyl)ammonium 3-hydroxynaphthoate
- CAS NO.：3818-50-6
- Empirical Formula: C28H29NO4
- Molecular Weight: 443.53
- MDL number: MFCD00078960
- EINECS: 223-306-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-02-28 13:03:53
What is BEPHENIUM HYDROXYNAPHTHOATE?
The Uses of BEPHENIUM HYDROXYNAPHTHOATE
antibacterial, antilepretic, antituberculosis
The Uses of BEPHENIUM HYDROXYNAPHTHOATE
Bephenium Hydroxynapthoate is an anthelmintic agent used to treat hookworm infections and ascariasis.
Indications
This drug exhibits antihelmintic action by acting as a cholinergic agonist, causing paralysis of the parasite musculature. This facilitates its removal from the intestines. It is used for treating ascariasis, ankylostomiasis, enterobiasis, trichostrongyliasis, and tricocefalosis. A single dose of bephenium heals from 80 to 100% of patients infected with A. duodenale. It is less effective with respect to N. americanus. Synonyms of this drug are aclopar and others.
Clinical Use
Bephenium can be used against Ascaris, Ancylostoma, and Trichostrongylus infections; it is less effective against Necator. Occasional adverse reactions occur: nausea, diarrhea, vomiting, headache, vertigo.
Synthesis
Bephenium, 3-hydroxy-2-naphthoat benzyldimethyl(2-phenoxyethyl) ammonia (38.1.37), is made by reacting the sodium salt of 3-hydroxy-2-naphthoic acid with benzyldimethyl(2-phenoxyethyl)ammonia chloride (38.1.36). This is in turn made from benzyl chloride and N-(2-phenoxyethyl)dimethylamine (38.1.35), which is synthesized by reacting sodium phenolate with 2-dimethylaminoethylchloride.
Properties of BEPHENIUM HYDROXYNAPHTHOATE
| Melting point: | 170-171° |
| storage temp. | Store at -20°C |
| solubility | ≥ 20.85mg/mL in DMSO |
| form | Solid |
| form | neat |
| color | White to off-white |
Safety information for BEPHENIUM HYDROXYNAPHTHOATE
Computed Descriptors for BEPHENIUM HYDROXYNAPHTHOATE
New Products
Cyclopentane-1,2-dione 8-hydroxy-7-methoxy-2,6-dimethylisoquinolinium iodide Isopropyl amine Hydrochloride 2-Bromo-5-iodopyridine 3-Aminophenylacetic acid 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Amino-4-methoxyben-zeneacetic acid 1-AMino-cyclobutaneMethanol HCl (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid Rifaximin EP Impurity-G N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 2-(3-amino propyl amino) ethyl bromide tri sodium thio phosphate 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 2,2'-(5-Bromomethyl-1,3-phenylene)-di(2-Methylpropionitrile) L-phenylalanine, N-(pyrazinyl carbonyl) methyl ester 3,4 Diethoxy Benzylcyanide 3,4 Dimethoxy Benzylcyanide valeronitrileRelated products of tetrahydrofuran
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