BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-

CAS NO.：915759-45-4
Empirical Formula: C18H19F3N2O4S2
Molecular Weight: 448.48
MDL number: MFCD18206894
EINECS: 1592732-453-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-14 16:49:18

What is BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-?

Description

WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP-1; IC₅₀ = 0.5 μM). It increases Wnt signaling in U2OS osteosarcoma cells (EC₅₀ = 0.65 μM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM.

Definition

ChEBI: WAY-316606 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonic acid with the primary amino group of piperidin-4-amine. An inhibitor of secreted Frizzled-Related Protein-1 (sFRP-1). It has a role as a secreted frizzled-related protein 1 inhibitor. It is a sulfone, a sulfonamide, a member of (trifluoromethyl)benzenes, a member of piperidines and a secondary amino compound.

Properties of BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-

Boiling point:	601.1±65.0 °C(Predicted)
Density	1.50±0.1 g/cm3(Predicted)
solubility	DMF: 3 mg/ml; DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
form	Powder
pka	8.76±0.20(Predicted)
color	White to off-white

Safety information for BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-

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