WAY-151932
- CAS NO.：220460-92-4
- Empirical Formula: C23H19ClN4O
- Molecular Weight: 402.88
- MDL number: MFCD05662330
- Update Date: 2025-10-28 16:00:23
What is WAY-151932?
Biological Activity
WAY-151932 is an antidiuretic hormone V2 receptor agonist with IC50 of 80.3 and 778 nM in human V2 and V1a binding assays, respectively.
in vitro
WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV 2 receptors in a dose-dependent manner with an EC 50 of 0.74±0.07 nM.
in vivo
Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED 50 =0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile.
Properties of WAY-151932
| Boiling point: | 630.6±55.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 0.04±0.12(Predicted) |
| color | White to off-white |
Safety information for WAY-151932
Computed Descriptors for WAY-151932
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