Benperidol
Synonym(s):1-{1-[4-(4-Fluorophenyl)-4-oxobutyl]-piperidin-4-yl}-1,3-dihydro-benzimidazol-2-one
- CAS NO.：2062-84-2
- Empirical Formula: C22H24FN3O2
- Molecular Weight: 381.44
- MDL number: MFCD00866672
- EINECS: 218-172-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-03 11:24:09
What is Benperidol?
Chemical properties
White or almost white powder.
Originator
Frenactil,Clin-Comar-Byla,France,1965
The Uses of Benperidol
Antipsychotic.
Background
Benperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.
Definition
ChEBI: 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one is an aromatic ketone.
Manufacturing Process
A mixture of 3.4 parts of γ-chloro-4-fluorobutyrophenone, 4 parts of 1-(4- piperidyl)-2-benzimidazolinone hydrochloride, 6 parts of sodium carbonate and 0.1 part of potassium iodide in 176 parts of 4-methyl-2-pentanone is stirred and refluxed for 48 hours. The reaction mixture is cooled and 120 parts of water is added. The separated organic layer is dried over magnesium sulfate and the solvent is evaporated to leave an oily residue which is dissolved in dilute hydrochloric acid and boiled. The acidic solution is filtered and cooled at room temperature whereupon there crystallizes from solution 1-(1-[γ-(4- fluorobenzoyl)propyl] -4-piperidyl)-2-benzimidazolinone hydrochloride hydrate melting at about 134°-142°C.
Therapeutic Function
Tranquilizer
Metabolism
Not Available
Properties of Benperidol
| Melting point: | 170-171.8° |
| Boiling point: | 230.3°C (rough estimate) |
| Density | 1.1876 (estimate) |
| storage temp. | Store at -20°C |
| solubility | Practically insoluble in water, freely soluble in dimethylformamide, soluble in methylene chloride, slightly soluble in ethanol (96 per cent). |
| form | neat |
| pka | 12.04±0.30(Predicted) |
| form | Solid |
| color | White to off-white |
| CAS DataBase Reference | 2062-84-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Benperidol(2062-84-2) |
Safety information for Benperidol
Computed Descriptors for Benperidol
New Products
1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Dibenzo[b,f][1,4]thiazepin-11(10H)-one Cis-Tosylate Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 1-Benzhydrylazetane-3-carbonitrile 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione (±)-amino(2-fluorophenyl)acetic acid 2-(2-Chlorophenyl)glycine AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 2'-Fluoroacetophenone METHANOL-D1(OD) N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D BENZENE-D6 TOLUENE-D3 2-Hydroxybutanenitrile 1-Benzylindolin-2-one Ethyl 2-bromo-3-oxobutanoate 4-(3-chloropropyl)morpholine 1-Benzylindoline-2,3-dione 3-Oxocyclobutanecarboxylic acid 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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