bamifylline hydrochloride
- CAS NO.：20684-06-4
- Empirical Formula: C20H27N5O3.ClH
- Molecular Weight: 421.926
- EINECS: 243-967-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-04 19:55:51
What is bamifylline hydrochloride?
Originator
Bamifylline,ZYF Pharm Chemical
The Uses of bamifylline hydrochloride
Bronchodilator.
Manufacturing Process
A mixture of 100 kg of 8-benzyltheophilline, 36 L of N-ethylethanolamine, 300 L of 1,2-dichlorethane and 71 kg of sodium carbonate was refluxed for 24 hours. Then 36 L of N-ethylethanolamine was added and the reaction mixture was refluxed. After cooling to the mixture was added the water and hydrochloric acid. The organic phase was extracted with hydrochloric acid. The acidic phase was neutralized with sodium carbonate and the 7-(N-ethyl-N-β- hydroxyethylaminoethyl)-8-benzyltheophilline was extracted with dichloromethane. The solvent was evaporated and the free base of 7-(N-ethyl- N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was dissolved in methanol. Hydrochloride of 7-(N-ethyl-N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was obtained by addition to the solution the hydrochloric acid; yield 81%, melting point 185-186°C.
Therapeutic Function
Bronchodilator, Coronary vasodilator
Properties of bamifylline hydrochloride
| Melting point: | 185-186° |
Safety information for bamifylline hydrochloride
Computed Descriptors for bamifylline hydrochloride
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