ATPA
Synonym(s):(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
- CAS NO.：140158-50-5
- Empirical Formula: C10H16N2O4
- Molecular Weight: 228.25
- MDL number: MFCD01860864
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 19:39:08
What is ATPA?
The Uses of ATPA
(R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent.
What are the applications of Application
(R,S)-ATPA is a potent and selective agonist of the GluR5 subtype of the kainate receptor
Definition
ChEBI: 2-amino-3-(5-tert-butyl-3-oxo-4-isoxazolyl)propanoic acid is an alpha-amino acid.
Biological Activity
A selective and potent GluR5 kainate receptor agonist (K i = 4.3 nM), inactive at GluR6 (K i > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (K i values of 6 - 14 μ M). Also available as part of the Kainate Receptor Tocriset™ .
Storage
Desiccate at +4°C
Properties of ATPA
| Density | 1.263±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at +4°C |
| solubility | DMSO: 10 mg/mL |
| form | solid |
| pka | 2.15±0.10(Predicted) |
| color | white |
Safety information for ATPA
Computed Descriptors for ATPA
New Products
1,3-Dichloroacetone Ethylene Ketal 1-N-Boc-3-(aminoethyl)azetidine 4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN AMino-(3-Methylphenyl)-acetic acid 3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 4, 4'-Ditolylamine (or) 4,4-Dimethyl Diphenylamine 2-Bromo-5-Chloropyridine 2-Picolinic acid N-oxide 4-Butyl Resorcinol 2-(2,4-Diaminophenoxy)ethanol Dihydrochloride 5-Bromo-2-Hydroxy-3-Nitro Pyridine 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile Tetracaine Hydrochloride Ep Grade 2,2,2-Trichloroethyl chloroformate 5-Bromo-4-chloro-3-indolyl-β-D-galactopyranoside 4-Pentyn-1-ol 2-Bromo-6-fluoroaniline 5-fluoro-1,3-benzodioxole 5-Phenyl-[1,3,4]-thiadiazol-2-amine 2-Chloro-6-nitro benzothiazole 2-(Chloromethyl) quinazolin-4(3H)-one 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinolineRelated products of tetrahydrofuran
![(R,S)-2-AMINO-3-[5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL]PROPIONIC ACID](https://img.chemicalbook.in/StructureFile/ChemBookStructure6/GIF/CB5396117.gif)
You may like
-
944401-57-4 98+View Details
944401-57-4 -
1,3-Dichloroacetone Ethylene Ketal 26271-50-1 98+View Details
26271-50-1 -
68208-20-8 3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 98+View Details
68208-20-8 -
7292-73-1 98+View Details
7292-73-1 -
68208-20-8 3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 98+View Details
68208-20-8 -
7292-73-1 98+View Details
7292-73-1 -
68208-20-8 3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 98+View Details
68208-20-8 -
7292-73-1 98+View Details
7292-73-1
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.