ATPA
Synonym(s):(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
- CAS NO.：140158-50-5
- Empirical Formula: C10H16N2O4
- Molecular Weight: 228.25
- MDL number: MFCD01860864
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 09:27:42
What is ATPA?
The Uses of ATPA
(R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent.
What are the applications of Application
(R,S)-ATPA is a potent and selective agonist of the GluR5 subtype of the kainate receptor
Definition
ChEBI: 2-amino-3-(5-tert-butyl-3-oxo-4-isoxazolyl)propanoic acid is an alpha-amino acid.
Biological Activity
A selective and potent GluR5 kainate receptor agonist (K i = 4.3 nM), inactive at GluR6 (K i > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (K i values of 6 - 14 μ M). Also available as part of the Kainate Receptor Tocriset™ .
Storage
Desiccate at +4°C
Properties of ATPA
| Density | 1.263±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at +4°C |
| solubility | DMSO: 10 mg/mL |
| form | solid |
| pka | 2.15±0.10(Predicted) |
| color | white |
Safety information for ATPA
Computed Descriptors for ATPA
New Products
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![(R,S)-2-AMINO-3-[5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL]PROPIONIC ACID](https://img.chemicalbook.in/StructureFile/ChemBookStructure6/GIF/CB5396117.gif)
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