ANTAZOLINE PHOSPHATE
Synonym(s):2-(N-Benzylanilinomethyl)-2-imidazoline;Antazoline phosphate salt
- CAS NO.：154-68-7
- Empirical Formula: C17H22N3O4P
- Molecular Weight: 363.35
- MDL number: MFCD00054317
- EINECS: 205-831-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:59:10
What is ANTAZOLINE PHOSPHATE?
The Uses of ANTAZOLINE PHOSPHATE
Antazoline Phosphate acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.
General Description
Antazoline phosphate, 2-[(Nbenzylanilino)methyl]-2-imidazoline dihydrogen phosphate,is a bitter, white to off-white crystalline powder thatis soluble in water. It has a pKa of 10.0, and a 2% solutionhas a pH of about 4.5. Antazoline, like the ethylenediamines,contains an N-benzylanilino group linked to a basicnitrogen through a two-carbon chain.
Antazoline is less active than most of the other antihistaminicdrugs, but it is characterized by the lack of local irritation.The more soluble phosphate salt is applied topicallyto the eye in a 0.5% solution. The less soluble hydrochlorideis given orally. In addition to its use as an antihistamine, antazolinehas more than twice the local anesthetic potency ofprocaine and also exhibits anticholinergic actions.
Properties of ANTAZOLINE PHOSPHATE
| Melting point: | 194-198° |
| storage temp. | Refrigerator |
| solubility | DMSO, Methanol |
| form | neat |
| color | White |
| CAS DataBase Reference | 154-68-7(CAS DataBase Reference) |
Safety information for ANTAZOLINE PHOSPHATE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ANTAZOLINE PHOSPHATE
New Products
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