alpha,alpha'-Dibromo-p-xylene
Synonym(s):p-Xylylene dibromide;1,4-Bis(bromomethyl)benzene;DMF
- CAS NO.：623-24-5
- Empirical Formula: C8H8Br2
- Molecular Weight: 263.96
- MDL number: MFCD00000182
- EINECS: 210-781-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:50
What is alpha,alpha'-Dibromo-p-xylene?
Chemical properties
α,α′-Dibromo-p-xylene is a white to light yellow crystal powde,it reacts with nucleophiles such as chloride leads to the formation of diphenyl ethers.
The Uses of alpha,alpha'-Dibromo-p-xylene
alpha,alpha'-Dibromo-p-xylene is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 7055, 1994 DOI: 10.1016/0040-4039(94)88224-X
Synthesis
The synthesis of alpha,alpha'-Dibromo-p-xylene begins with the reaction of pyridinedicarboxylic acid and bromine in the presence of an organic solvent. This reaction yields a mixture comprising diphenyl ethers and other halogenated aromatic compounds, which can subsequently be purified through crystallization or distillation methods.
Purification Methods
Distil it under a vacuum and recrystallise it from EtOH, *benzene or chloroform. [Wenner Org Chem 17 527 1952, Beilstein 5 H 385, 5 I 187, 5 II 301, 5 III 859, 5 IV 970.]
Properties of alpha,alpha'-Dibromo-p-xylene
| Melting point: | 143-145 °C(lit.) |
| Boiling point: | 245 °C(lit.) |
| Density | 2.012 |
| refractive index | 1.614 |
| Flash point: | 155-158°C/14mm |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | dioxane: soluble1g/10 mL (hot) |
| form | Crystalline Powder and Coarse Crystals |
| color | White to beige |
| Water Solubility | soluble, hydrolyses |
| Sensitive | Lachrymatory |
| BRN | 1100019 |
| CAS DataBase Reference | 623-24-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1,4-bis(bromomethyl)-(623-24-5) |
| EPA Substance Registry System | 1,4-Bis(bromomethyl)benzene (623-24-5) |
Safety information for alpha,alpha'-Dibromo-p-xylene
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for alpha,alpha'-Dibromo-p-xylene
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