alpha,alpha'-Dibromo-p-xylene

Synonym(s):p-Xylylene dibromide;1,4-Bis(bromomethyl)benzene;DMF

CAS NO.：623-24-5
Empirical Formula: C8H8Br2
Molecular Weight: 263.96
MDL number: MFCD00000182
EINECS: 210-781-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-04 16:00:12

alpha,alpha'-Dibromo-p-xylene Structural

What is alpha,alpha'-Dibromo-p-xylene?

Chemical properties

α,α′-Dibromo-p-xylene is a white to light yellow crystal powde,it reacts with nucleophiles such as chloride leads to the formation of diphenyl ethers.

The Uses of alpha,alpha'-Dibromo-p-xylene

alpha,alpha'-Dibromo-p-xylene is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 7055, 1994 DOI: 10.1016/0040-4039(94)88224-X

Synthesis

The synthesis of alpha,alpha'-Dibromo-p-xylene begins with the reaction of pyridinedicarboxylic acid and bromine in the presence of an organic solvent. This reaction yields a mixture comprising diphenyl ethers and other halogenated aromatic compounds, which can subsequently be purified through crystallization or distillation methods.

Purification Methods

Distil it under a vacuum and recrystallise it from EtOH, *benzene or chloroform. [Wenner Org Chem 17 527 1952, Beilstein 5 H 385, 5 I 187, 5 II 301, 5 III 859, 5 IV 970.]

Properties of alpha,alpha'-Dibromo-p-xylene

Melting point:	143-145 °C(lit.)
Boiling point:	245 °C(lit.)
Density	2.012
refractive index	1.614
Flash point:	155-158°C/14mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	dioxane: soluble1g/10 mL (hot)
form	Crystalline Powder and Coarse Crystals
color	White to beige
Water Solubility	soluble, hydrolyses
Sensitive	Lachrymatory
BRN	1100019
CAS DataBase Reference	623-24-5(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1,4-bis(bromomethyl)-(623-24-5)
EPA Substance Registry System	1,4-Bis(bromomethyl)benzene (623-24-5)

Safety information for alpha,alpha'-Dibromo-p-xylene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.