alpha-Methyldopa sesquihydrate
Synonym(s):α-Methyl-L -DOPA;L -α-Methyl-DOPA;3-(3,4-Dihydroxyphenyl)-2-methyl-L -alanine;Methyl-L -DOPA;MK-351
- CAS NO.：41372-08-1
- Empirical Formula: C10H15NO5
- Molecular Weight: 229.23
- MDL number: MFCD30179484
- EINECS: 609-918-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 15:00:32
What is alpha-Methyldopa sesquihydrate?
Chemical properties
White Solid
The Uses of alpha-Methyldopa sesquihydrate
Antihypertensive agent
The Uses of alpha-Methyldopa sesquihydrate
Potent inhibitor of invertase and glucosidase inhibitor with a different specificity of action to DNJ and castanospermine. Inhibits glucosidase I.
The Uses of alpha-Methyldopa sesquihydrate
Antihypertensive agent.
What are the applications of Application
L-α-Methyl-DOPA ? sesquihydrate is an L-aromatic amino acid decarboxylase inhibitor and an adrenergic inhibiting agent
Biological Activity
l-(-)-α-methyldopa (hydrate) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.
Purification Methods
Recrystallise methyldopa from H2O. [Reinhold et al. J Org Chem 33 1209 1968.] The L-isomer forms a sesquihydrate from H2O m 302-304o (dec), and the anhydrous crystals are hygroscopic,[] 23D -4.0o (c 1, 0.1N HCl), []546 +154.5o (c 5, CuSO4 solution). It has max at 281nm ( 2780). Its solubility in H2O at 25o is ~10mg/mL and the pH of an aqueous solution is ~5.0. It is insoluble in most organic solvents. [Stein et al. J Am Chem Soc 77 700 1955, Beilstein 4 IV 2505.]
Properties of alpha-Methyldopa sesquihydrate
| Melting point: | >300 °C(lit.) |
| storage temp. | 2-8°C |
| solubility | Slightly soluble in water, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute mineral acids. |
| form | neat |
| form | Solid |
| color | White to Off-White |
| optical activity | [α]25/D 13°, c = 1 in H2O |
| Water Solubility | 0.1-1 g/100 mL at 23 ºC |
| Sensitive | Air & Light Sensitive |
| Merck | 13,6080 |
| BRN | 2417244 |
| Stability: | Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere. |
| CAS DataBase Reference | 41372-08-1(CAS DataBase Reference) |
Safety information for alpha-Methyldopa sesquihydrate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for alpha-Methyldopa sesquihydrate
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