alpha-Bisabolol

Description

Bisabolol, a derivative of?Matricaria chamomilla?(German chamomile), helps administer active pharmaceutical ingredients transdermally by enhancing skin penetration. Bisabolol is also found in some lotions for reducing wrinkles and acne.

Chemical properties

colourless to faintly yellow viscous liquid

The Uses of alpha-Bisabolol

alpha-Bisabolol is a botanical used for its anti-inflammatory and soothing properties. It is derived from chamomile and/or yarrow.

The Uses of alpha-Bisabolol

It finds its application as a masking agent, skin conditioning agent and soothing agent in cosmetics industry. The most important effects of Bisabolol for the use in cosmetics are anti-inflammatory, wound-healing, anti-bacterial and anti-mycotic. Bisabolol is therefore perfectly suited for the use in all kinds of skin-care products It can be used as active substance in cosmetic preparations for the protection and care of sensitive skin, preparations for babies and children, sunscreen and after-sun products, aftershaves and preparations for the oral hygiene.

Definition

ChEBI: (+)-alpha-Bisabolol is a sesquiterpenoid.

Production Methods

rac-Bisabolol is produced by acid-catalyzed cyclization of farnesol or nerolidol. The individual enantiomers are obtained by extraction from the appropriate plants.

Preparation

Via Nerolidol plus glacial Acetic acid with Sulfuric acid to yield Bisabolol acetate, Saponification of that ester yields alpha-Bisabolol.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andirritating vapors.