Albendazole
Synonym(s):Albendazole;Methyl 5-(propylthio)-2-benzimidazolecarbamate
- CAS NO.:54965-21-8
- Empirical Formula: C12H15N3O2S
- Molecular Weight: 265.33
- MDL number: MFCD00083232
- EINECS: 259-414-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-06 16:20:44
What is Albendazole?
Absorption
Poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. Oral bioavailability appears to be enhanced when coadministered with a fatty meal (estimated fat content 40 g)
Toxicity
Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.
The Uses of Albendazole
Albendazole is a derivative of benzimidazole, is a drug with a broad antihelmintic spectrum. It exhibits an antihelmintic effect against sensitive cestodes and nematodes by blocking the process of glucose uptake by the parasites, which is expressed in the depletion of glycogen reserves and subsequent reduction in the level of adenosintriphophate. As a result, the parasite stops moving and dies. It is used upon infection of Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, and Trichuris trichiura. Synonyms of this drug are SKF 62979 and others.
Background
Albendazole is a benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases.
Indications
For the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, Taenia solium and for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, Echinococcus granulosus.
Pharmacokinetics
Albendazole is a broad-spectrum anthelmintic. The principal mode of action for albendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.
Metabolism
Hepatic. Rapidly converted in the liver to the primary metabolite, albendazole sulfoxide, which is further metabolized to albendazole sulfone and other primary oxidative metabolites that have been identified in human urine.
Properties of Albendazole
Melting point: | 208-210 °C |
Density | 1.2561 (rough estimate) |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, freely soluble in anhydrous formic acid, very slightly soluble in methylene chloride, practically insoluble in ethanol (96 per cent). |
form | neat |
color | White to Off-White |
Water Solubility | 0.75mg/L(209 ºC) |
Safety information for Albendazole
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 Environment GHS09 |
GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P391:Collect spillage. Hazardous to the aquatic environment P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Albendazole
InChIKey | HXHWSAZORRCQMX-UHFFFAOYSA-N |
SMILES | C(OC)(=O)NC1NC2=CC(SCCC)=CC=C2N=1 |
Abamectin manufacturer
SNECOFRi PVT LTD
KARPSCHEM LABORATORIES PVT. LTD.
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