Alantolactone
Synonym(s):(+)-Alantolactone.;3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one;Alant camphor;Elecampane camphor;Eupatal
- CAS NO.：546-43-0
- Empirical Formula: C15H20O2
- Molecular Weight: 232.32
- MDL number: MFCD00274568
- EINECS: 208-899-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 09:27:42
What is Alantolactone?
Description
The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone-mix, used to detect sensitization to Compositae.
Chemical properties
Crystalline powder
The Uses of Alantolactone
Alantolactone is sesquiterpene lactone that possesses anti-inflammatory property. Alantolactone have been studied to be developed as a novel agent against human liver cancer.
The Uses of Alantolactone
anthelmintic, antibacterial, antineoplastic
The Uses of Alantolactone
Alantolactone has been used:
- in cell viability assay
- to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)
- in assessment of degranulation
Definition
ChEBI: A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Contact allergens
The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone mix used to detect sensitization to Compositae-Asteraceae.
Biochem/physiol Actions
Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.
Solubility in organics
Soluble in alcohol and essential oils
Storage
Store at -20°C
Properties of Alantolactone
| Melting point: | 78-79 C |
| Boiling point: | 275 C |
| alpha | D +175° (chloroform) |
| Density | 1.0610 (rough estimate) |
| refractive index | 1.4360 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: soluble15mg/mL (clear solution) |
| form | powder |
| color | white to beige |
| Odor | Peculiar sweet-minty, slightly woody odor |
| CAS DataBase Reference | 546-43-0(CAS DataBase Reference) |
Safety information for Alantolactone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P501:Dispose of contents/container to..… |
Computed Descriptors for Alantolactone
Alantolactone manufacturer
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