Alantolactone

Synonym(s):(+)-Alantolactone.;3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one;Alant camphor;Elecampane camphor;Eupatal

CAS NO.：546-43-0
Empirical Formula: C15H20O2
Molecular Weight: 232.32
MDL number: MFCD00274568
EINECS: 208-899-3
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-05 14:33:18

What is Alantolactone?

Description

The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone-mix, used to detect sensitization to Compositae.

Chemical properties

Crystalline powder

The Uses of Alantolactone

anthelmintic, antibacterial, antineoplastic

The Uses of Alantolactone

Alantolactone has been used:

in cell viability assay
to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)
in assessment of degranulation

The Uses of Alantolactone

Alantolactone is sesquiterpene lactone that possesses anti-inflammatory property. Alantolactone have been studied to be developed as a novel agent against human liver cancer.

Definition

ChEBI: A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.

Contact allergens

Solubility in organics

Soluble in alcohol and essential oils

Storage

Store at -20°C

Properties of Alantolactone

Melting point:	78-79 C
Boiling point:	275 C
alpha	D +175° (chloroform)
Density	1.0610 (rough estimate)
refractive index	1.4360 (estimate)
storage temp.	-20°C
solubility	DMSO: soluble15mg/mL (clear solution)
form	powder
color	white to beige
Odor	Peculiar sweet-minty, slightly woody odor
CAS DataBase Reference	546-43-0(CAS DataBase Reference)

Safety information for Alantolactone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H317:Sensitisation, Skin
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P501:Dispose of contents/container to..…