Adipic dihydrazide
Synonym(s):Adipic dihydrazide;Hexanedioic acid dihydrazide
- CAS NO.:1071-93-8
- Empirical Formula: C6H14N4O2
- Molecular Weight: 174.2
- MDL number: MFCD00007614
- EINECS: 213-999-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-01 08:52:44
What is Adipic dihydrazide?
Description
Adipic dihydrazide (ADH) is the most suitable hydrazide cross-linking agent, and ADH has been widely used in water-based paint emulsions in combination with diacetone acrylamide. ADH is weakly alkaline, and there is a possibility of agglomeration when solid ADH is added directly to the emulsion, so usually ADH should be dissolved in hot water before use.
Chemical properties
white to slightly yellow crystalline powder
The Uses of Adipic dihydrazide
Adipic dihydrazide is used as a formaldehyde scavenger and reacts with formaldehyde, thereby preventing the volatilizing of formaldehyde in the air. It is also employed as a paint additive and coating additive. It is also used as an intermediate. Further, it is used for cross-linking water-based emulsions and as a hardener for certain epoxy resins, which finds application in powder coating.
The Uses of Adipic dihydrazide
Adipic acid dihydrazide is a homobifunctional cross-linking reagent specific for aldehydes resulting in relatively stable hydrazone linkages. Adipic acid dihydrazide is typically, used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation. Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.
Flammability and Explosibility
Non flammable
Properties of Adipic dihydrazide
| Melting point: | 180-182 °C (lit.) |
| Boiling point: | 305.18°C (rough estimate) |
| Density | 1.2297 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.6700 (estimate) |
| Flash point: | 150 °C |
| storage temp. | -20°C |
| solubility | H2O: 100 mg/mL |
| form | Crystalline Powder |
| pka | 12.93±0.35(Predicted) |
| color | White to slightly yellow |
| Water Solubility | soluble |
| BRN | 973863 |
| CAS DataBase Reference | 1071-93-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Adipic dihydrazide(1071-93-8) |
| EPA Substance Registry System | Hexanedioic acid, dihydrazide (1071-93-8) |
Safety information for Adipic dihydrazide
| Signal word | Warning |
| Pictogram(s) |
![]() Environment GHS09 |
| GHS Hazard Statements |
H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P501:Dispose of contents/container to..… |
Computed Descriptors for Adipic dihydrazide
| InChIKey | IBVAQQYNSHJXBV-UHFFFAOYSA-N |
Adipic dihydrazide manufacturer
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