Ac-DEVD-PNA
Synonym(s):Ac-DEVD-pNA
- CAS NO.：189950-66-1
- Empirical Formula: C26H34N6O13
- Molecular Weight: 638.58
- MDL number: MFCD00792707
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:54:01
What is Ac-DEVD-PNA?
The Uses of Ac-DEVD-PNA
N-Acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-nitrophenyl)-L-asparagine is an para-nitro aniline chromophore cleaved by caspase.
The Uses of Ac-DEVD-PNA
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide is an chromogenic substrate for Caspase 3 and CCP-32.
The Uses of Ac-DEVD-PNA
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide has been used as a chromogenic substrates for determining caspase-3 and caspase-8 activities in liver tissue homogenates and caspase 3 activity in aortic vascular smooth muscle cells and neuroblastoma cell lines.
What are the applications of Application
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases
Biochem/physiol Actions
Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
Properties of Ac-DEVD-PNA
| Boiling point: | 1191.1±65.0 °C(Predicted) |
| Density | 1.448±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 2.97±0.10(Predicted) |
| form | powder |
| color | white |
| Water Solubility | Soluble in water (partly), dimethyl sulfoxide, buffer, pH 7, and acetonitrile:methanol (1:1) (1 mg/ml). |
| Stability: | Hygroscopic |
Safety information for Ac-DEVD-PNA
Computed Descriptors for Ac-DEVD-PNA
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