Ac-DEVD-CHO
Synonym(s):Ac-DEVD-CHO;Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem;CPP32/Apopain Inhibitor, Ac-DEVD-CHO
- CAS NO.：169332-60-9
- Empirical Formula: C20H30N4O11
- Molecular Weight: 502.47
- MDL number: MFCD00671412
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:54:17
What is Ac-DEVD-CHO?
The Uses of Ac-DEVD-CHO
Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase
The Uses of Ac-DEVD-CHO
N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.
Definition
ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde. It is an inhibitor of caspase-3/7.
General Description
N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.
Biochem/physiol Actions
N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.
Properties of Ac-DEVD-CHO
| Boiling point: | 1021.1±65.0 °C(Predicted) |
| Density | 1.374±0.06 g/cm3(Predicted) |
| RTECS | EK7643000 |
| storage temp. | -20°C |
| solubility | H2O: 1 mg/mL |
| pka | 4.19±0.10(Predicted) |
| form | powder |
| color | white |
| Sensitive | Moisture Sensitive |
Safety information for Ac-DEVD-CHO
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Ac-DEVD-CHO
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