8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE

Description

8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase. At 1 μM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.

Chemical properties

White powder

The Uses of 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE

8-bromo-cGMP activates cGMP-dependent protein kinase. It can also inhibit acetylcholine-induced increases in intracellular calcium concentrations.

What are the applications of Application

8-Bromo-cGMP is a cell-permeable cGMP analog resistance to hydrolysis than cGMP

Definition

ChEBI: Sodium 8-bromo-3',5'-cyclic GMP is an organic sodium salt having 8-bromoguanosine 3',5'-cyclic phosphate as the counterion. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. It has a role as a protein kinase G agonist and a muscle relaxant. It contains an 8-bromo-3',5'-cyclic GMP(1-).

Biological Activity

Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1 α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro .

Storage

Desiccate at -20°C