7,8-DIHYDRO-L-BIOPTERIN

Description

BH₂ is a precursor of BH₄ synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a K_i of 14.4 μM.

Chemical properties

Yellow Powder

The Uses of 7,8-DIHYDRO-L-BIOPTERIN

An oxidation producct of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of G

The Uses of 7,8-DIHYDRO-L-BIOPTERIN

The reduced form of Biopterin. An oxidation product of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM.

The Uses of 7,8-DIHYDRO-L-BIOPTERIN

BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM.

What are the applications of Application

7,8-Dihydro-L-biopterin is a precursor of BH4 synthesis

Definition

ChEBI: L-erythro-7,8-dihydrobiopterin is a 7,8-dihydrobiopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form. It is an enantiomer of a D-erythro-7,8-dihydrobiopterin.

References

[1] shen r, alam a, zhang y. inhibition of gtp cyclohydrolase i by pterins[j]. biochimica et biophysica acta (bba)-general subjects, 1988, 965(1): 9-15.
[2] sugiyama t, levy b d, michel t. tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells[j]. journal of biological chemistry, 2009, 284(19): 12691-12700.