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HomeProduct name list6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt

6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt

6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt Structural

What is 6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt?

Description

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 μg/kg/min and 60 ng/ml, respectively.

The Uses of 6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt

Platelet aggregation inhibitor.

What are the applications of Application

Ciprostene (calcium salt) is a less potent, stable analog of PGI2

Properties of 6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt

storage temp.  Store at -20°C
solubility  DMF: > 25 mg/ml; DMSO: > 16.8 mg/ml; ethanol: > 34 mg/ml; PBS pH 7.2: > 0.29 μg/ml
form  A crystalline solid

Safety information for 6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt

Computed Descriptors for 6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt

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