Althiazide
- CAS NO.：5588-16-9
- Empirical Formula: C11H14ClN3O4S3
- Molecular Weight: 383.89
- MDL number: MFCD00063558
- EINECS: 226-994-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 19:39:08
What is Althiazide?
Description
Althiazide, also known as altizide, is an agent belonging to the class of thiazide diuretics with antihypertensive activity. This aldosterone antagonist is often combined with spironolactone.
Chemical properties
White Solid
Originator
Althiazide,Solchem
The Uses of Althiazide
Diuretic and antihypertensive.
What are the applications of Application
Althiazide is a diuretic and antihypertensive aromatic sulfur compound
Definition
ChEBI: Althiazide is a benzothiadiazine. It is the thiazide and sulfonamide derivative.
Manufacturing Process
To 6.75 g (0.0225 mole) of 4-amino-2-chloro-5-(methylsulfamyl) benzenesulfonamide in 45 ml of dimethylformamide is added 4.86 g (0.03 mole) of dimethyl allylmercaptoacetal followed by 1.5 ml ethyl acetate saturated with hydrogen chloride gas. The solution is refluxed for 1.5 hours, cooled and added dropwise with stirring to ice/water. The resulting precipitate is filtered, dried and recrystallized from isopropanol. The recrystallization gave 4.0 g of 2-methyl-3-allylthiomethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide; M.P. 168.5-170°C.
Therapeutic Function
Diuretic, Antihypertensive
Properties of Althiazide
| Melting point: | 206-207° |
| Boiling point: | 625.8±65.0 °C(Predicted) |
| Density | 1.502±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, soluble in methanol, practically insoluble in dichloromethane. |
| form | neat |
| pka | 8.33±0.40(Predicted) |
| color | White to Off-White |
| EPA Substance Registry System | 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-[(2-propen-1-ylthio)methyl]-, 1,1-dioxide (5588-16-9) |
Safety information for Althiazide
Computed Descriptors for Althiazide
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