6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
- CAS NO.：52853-40-4
- Empirical Formula: C7H8Br2N6
- Molecular Weight: 335.99
- MDL number: MFCD09833976
- EINECS: 692-499-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-14 17:34:31
What is 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide?
Description
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide is a potent inhibitor of the enzyme nitroaldolase (EC 1.2.1.22) and has been shown to inhibit cell growth in murine leukemia cells. This reaction is mediated by the addition of bromide to isobutyl esters, leading to a benzyl ester intermediate which undergoes an electrophilic attack on nitroaldolase. The mechanism of action for this drug involves the inhibition of membrane transport and chloride ion influx, which are necessary for the proliferation of tumor cells. 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide also inhibits DNA synthesis through its effects on thymidylate synthase, preventing nucleotide production from thymine and dihydrofolate reductase activity.
Chemical properties
Light Brown Solid
The Uses of 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide can be used as organic synthesis intermediate and pharmaceutical intermediate.
What are the applications of Application
6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide (Technical Grade) is a useful research chemical used in the preparation of novel methotrexate derivatives as antirheumatic agents as well as the preparation of pteridine reductase inhibitors.
Properties of 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
| Melting point: | >195°C (dec.) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Light Brown to Brown |
| InChI | InChI=1S/C7H7BrN6.BrH/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6;/h2H,1H2,(H4,9,10,11,13,14);1H |
Safety information for 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
| InChIKey | KMQIBGKVZDBGAH-UHFFFAOYSA-N |
| SMILES | NC1=NC(N)=NC2=NC=C(CBr)N=C12.Br |
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide manufacturer
ALS India Life Sciences Pvt. Ltd
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