6-Aminonicotinic acid
Synonym(s):6-Aminonicotinic acid
- CAS NO.：3167-49-5
- Empirical Formula: C6H6N2O2
- Molecular Weight: 138.12
- MDL number: MFCD00006326
- EINECS: 221-630-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is 6-Aminonicotinic acid?
Chemical properties
Light yellow Cryst
The Uses of 6-Aminonicotinic acid
6-Aminopyridine-3-carboxylic acid (6-Aminonicotinic acid) was used in the preparation of resin-bound 2-aminoazine.
The Uses of 6-Aminonicotinic acid
Antiproliferative
Definition
ChEBI: An aminonicotinic acid in which the amino group is situated at position 6 of the pyridine ring.
What are the applications of Application
6-Aminonicotinic acid is an inhibitor of bacterial DNA gyrase and topoisomerase IV. It has been shown to inhibit the growth of a number of bacteria, including E. coli K-12, with potent inhibitory activity against these enzymes. It binds to the active sites on these enzymes and prevents them from working. The detection time for 6-aminonicotinic acid is about 3 hours after exposure. It has been shown to be more potent than other inhibitors of bacterial DNA gyrase and topoisomerase IV such as 2,4-diaminopyrimidine (2,4DAP).
General Description
Electrosynthesis of 6-aminopyridine-3-carboxylic acid (6-aminonicotinic acid) by electrochemical reduction of 2-amino-5-bromo and 2-amino-5-chloropyridine in the presence of CO2 at silver electrode has been reported.
Purification Methods
Crystallise the acid from aqueous acetic acid. Dry it in vacuo at 70o. [Beilstein 22 III/IV 6726.]
Properties of 6-Aminonicotinic acid
| Melting point: | >300 °C (lit.) |
| Boiling point: | 253.51°C (rough estimate) |
| Density | 1.3471 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | Powder |
| pka | 2.86±0.10(Predicted) |
| color | White to beige |
| Water Solubility | ca 1.0 g/L (20 ºC) |
| Merck | 14,456 |
| BRN | 115992 |
| CAS DataBase Reference | 3167-49-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Nicotinic acid, 6-amino-(3167-49-5) |
| EPA Substance Registry System | 3-Pyridinecarboxylic acid, 6-amino- (3167-49-5) |
Safety information for 6-Aminonicotinic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 6-Aminonicotinic acid
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