5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE

CAS NO.：163769-88-8
Empirical Formula: C22H21N3O2
Molecular Weight: 359.42
MDL number: MFCD00354370
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 15:16:37

What is 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE?

Description

YM-90709 is a competitive antagonist of the interleukin-5 (IL-5) receptor that has IC₅₀ values of 1 and 0.57 μM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells, respectively, in a radioligand binding assay. It inhibits IL-5-induced eosinophil survival (IC₅₀ = 0.45 μM) and JAK2 phosphorylation in vitro. YM-90709 inhibits eosinophil and lymphocyte infiltration (ED₅₀s = 0.32 and 0.12 mg/kg, respectively) into the brochoalveolar lavage fluid (BALF) of rats and eosinophil infiltration (ED₅₀ = 0.05 mg/kg) into the BALF of mice in models of airway inflammation.

The Uses of 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE

YM 90709, is an interleukin-5 receptor antagonist.

What are the applications of Application

YM 90709 is a selective inhibitor of IL-5 (interleukin-5).

Definition

ChEBI: LSM-2128 is a quinoxaline derivative.

Biological Activity

Novel, selective inhibitor of interleukin-5 (IL-5) binding to its receptor (IC 50 = 0.45-1 mM). Inhibits IL-5-prolonged eosinophil survival and IL-5-induced tyrosine phosphorylation of JAK2 without inhibiting GM-CSF-mediated effects. In vivo, inhibits antigen-induced eosinophil and lymphocyte recruitment in rat airways, without affecting peripheral blood or bone marrow leukocytes.

Properties of 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE

Boiling point:	579.6±50.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml
form	A crystalline solid
pka	2.74±0.40(Predicted)
color	Brown to orange

Safety information for 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE

Computed Descriptors for 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE

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