YM 26734
Synonym(s):1,1′-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis1-dodecanone
- CAS NO.：144337-18-8
- Empirical Formula: C45H62O8
- Molecular Weight: 730.97
- MDL number: MFCD00918068
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-12 18:10:29
What is YM 26734?
The Uses of YM 26734
YM-26734 is a derivative of a compound isolated from the fruit of H. amygdaline that competitively inhibits rabbit platelet sPLA2 which is a diverse family of low molecular weight PLA2s with tissue-specific expression patterns and actions.
What are the applications of Application
YM 26734 is a competitive inhibitor of secretory phospholipase A2 (PLA2)
Biological Activity
Competitive inhibitor of secretory phospholipase A 2 (sPLA 2 ) that exhibits a broad inhibitory profile to several sPLA 2 s (IC 50 values are 0.2, 1, 1, 1 and 3 μ M for sPLA 2 -X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA 2 -IIF and no activity at cytosolic PLA 2 , cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.
Storage
Store at -20°C
Properties of YM 26734
| storage temp. | Store at -20°C |
| solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| form | Powder |
Safety information for YM 26734
Computed Descriptors for YM 26734
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