5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

Synonym(s):5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione;CG53353, DAPH 2, 4,5-bis(4-Fluoroanilino)-phthalimide, CGP 53 353;DAPH 2;PKC_βII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem

CAS NO.：145915-60-2
Empirical Formula: C20H13F2N3O2
Molecular Weight: 365.33
MDL number: MFCD00938569
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:59:15

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Structural

What is 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE?

The Uses of 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

CGP 53353 inhibited tyrosine kinase activity of the EGF-R in five different human transitional cell carcinoma lines.

What are the applications of Application

DAPH-7 is a highly selective PKCβII inhibitor

Definition

ChEBI: 5,6-bis(4-fluoroanilino)isoindole-1,3-dione is a member of phthalimides.

Biological Activity

Selective inhibitor of PKC β II (IC 50 values are 0.41 and 3.8 μ M for PKC β II and PKC β I respectively). Also inhibits prionogenic Sup35 fibrillization (IC 50 ~ 3.4 μ M) and inhibits de novo A β 42 assembly in vitro .

Storage

Store at RT

Properties of 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

storage temp.	2-8°C
solubility	DMSO: >10mg/mL
form	solid
color	orange

Safety information for 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

Computed Descriptors for 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

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5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

4-FLUORODIPHENYLAMINE

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

Synonym(s):5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione;CG53353, DAPH 2, 4,5-bis(4-Fluoroanilino)-phthalimide, CGP 53 353;DAPH 2;PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem

What is 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE?

The Uses of 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

What are the applications of Application

Definition

Biological Activity

Storage

Properties of 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

Safety information for 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

Computed Descriptors for 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

New Products

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Synonym(s):5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione;CG53353, DAPH 2, 4,5-bis(4-Fluoroanilino)-phthalimide, CGP 53 353;DAPH 2;PKC_βII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem