5-METHOXYQUINOLIN-8-AMINE
Synonym(s):5-Methoxy-8-quinolinamine;Chen Auxilliary;Gong Chen Auxiliary;MQ;MQ Auxiliary
- CAS NO.：30465-68-0
- Empirical Formula: C10H10N2O
- Molecular Weight: 174.2
- MDL number: MFCD01593679
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:12:48
What is 5-METHOXYQUINOLIN-8-AMINE?
The Uses of 5-METHOXYQUINOLIN-8-AMINE
The Chen auxiliary was reported to be an effective directing group in the synthesis of pyrrolidones from assisting in the activation of C(sp3)-H bonds and can be readily installed through amide bond formation and removed through mild conditions using CAN at room temperature.
General Description
8-Amino-5-methoxyquinoline is a substituted quinoline derivative that can be prepared using 5-chloro-2-nitroaniline as a starting material. It can act as an easily removable directing group and also mediate C-H activation. These properties have been useful for synthesizing isomeric dibenzoxazepinones and complex pyrrolidinones from compounds containing 8-amino-5-methoxyquinoline moiety.
Properties of 5-METHOXYQUINOLIN-8-AMINE
| Melting point: | 90-95°C |
| Boiling point: | 355.7±27.0 °C(Predicted) |
| Density | 1.217±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 3.98±0.12(Predicted) |
| form | powder |
Safety information for 5-METHOXYQUINOLIN-8-AMINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-METHOXYQUINOLIN-8-AMINE
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