5-METHOXY-2-METHYLINDOLE

Synonym(s):NSC 63817

CAS NO.：1076-74-0
Empirical Formula: C10H11NO
Molecular Weight: 161.2
MDL number: MFCD00005620
EINECS: 214-066-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:59:00

What is 5-METHOXY-2-METHYLINDOLE?

Description

5-methoxy-2-methylindole is a useful organic raw material. It can be used as the reactant in the preparation of indolylquinoxalines by condensation reactions, in preparation of alkylindoles via Ir-catalyzed reductive alkylation, in arylation reactions in the presence of a palladium acetate catalyst, in enantioselective Friedel-Crafts alkylation, as well as in stereo selective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. It is also employed in inhibiting the chlorinating activity of myeloperoxidase (MPO) and in the metabolic synthesis of acrylacetic acid anti-inflammatory synthesis.

Chemical properties

white to light beige crystalline powder or

The Uses of 5-METHOXY-2-METHYLINDOLE

An indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid antiinflammatory synthesis.

The Uses of 5-METHOXY-2-METHYLINDOLE

reactant in preparation of indolylquinoxalines by condensation reactions1reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation2reactant in arylation reactions using a palladium acetate catalyst3reactant in enantioselective Friedel-Crafts alkylation4reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation5

The Uses of 5-METHOXY-2-METHYLINDOLE

It is employed as a reactant in preparation of indolylquinoxalines by condensation reactions, reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation, reactant in arylation reactions using a palladium acetate catalyst, reactant in enantioselective Friedel-Crafts alkylation and reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. As an indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid anti-inflammatory synthesis.

Definition

ChEBI: 5-Methoxy-2-methyl-1H-indole is a member of indoles.

References

https://www.alfa.com/en/catalog/B21348/
http://www.sigmaaldrich.com/catalog/product/aldrich/m15451?lang=en&region=US
https://pubchem.ncbi.nlm.nih.gov/compound/5-Methoxy-2-methylindole#section=2D-Structure

Properties of 5-METHOXY-2-METHYLINDOLE

Melting point:	86-88 °C (lit.)
Boiling point:	145 °C / 1.5mmHg
Density	1.0840 (rough estimate)
refractive index	1.5200 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in methanol (very faint turbidity.)
form	Crystalline Powder or Crystals
pka	17.28±0.30(Predicted)
color	White to light beige
CAS DataBase Reference	1076-74-0(CAS DataBase Reference)

Safety information for 5-METHOXY-2-METHYLINDOLE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.