5-ISOPROPYL-1,3-CYCLOHEXANEDIONE

The Uses of 5-ISOPROPYL-1,3-CYCLOHEXANEDIONE

5-Isopropyl-1,3-cyclohexanedione may be used as starting reagent for the synthesis of carvotanacetone analogs. It may be used in the preparation of monocyclic terepenes. It may be used in the synthesis of 2H-pyrans, via reaction with α,β-unsaturated aldehydes.

What are the applications of Application

5-Isopropyl-1,3-cyclohexanedione is a reagent used to initiate synthesis of carvotanacetone analogs

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 1645, 1950 DOI: 10.1021/ja01160a060

General Description

5-Isopropyl-1,3-cyclohexanedione is a cyclic 1,3-diketone. It can be prepared by condensation of isobutylideneacetone with ethyl malonate. 5-Isopropyl-1,3-cyclohexanedione on methylation with methyl iodide yields 5-isopropyl-2-methyl-1,3-cyclohexanedione. A multistep-synthesis of 5-isopropyl-1,3-cyclohexanedione involving aldol condensation, Dieckmann-type annulation, ester hydrolysis and decarboxylation is reported.