5-Fluoro-1,3-isobenzofurandione
- CAS NO.：319-03-9
- Empirical Formula: C8H3FO3
- Molecular Weight: 166.11
- MDL number: MFCD00191363
- EINECS: 1312995-182-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:21:35
What is 5-Fluoro-1,3-isobenzofurandione?
Chemical properties
white to light yellow crystal powder
The Uses of 5-Fluoro-1,3-isobenzofurandione
4-Fluorophthalic anhydride is used in the preparation of 5-fluoro-2-pyridin-3-ylmethyl-isoindole-1,3-dione by reacting with C-pyridin-3-yl-methylamine.
The Uses of 5-Fluoro-1,3-isobenzofurandione
4-Fluorophthalic anhydride can be used as a reactant to prepare:
- 4-amino substituted phthalimides applicable as potential fluorescent probes and fluorescent bioactive compounds.
- 4,4′-bis(4-fluorophthalimido)diphenyl ether monomer, which is used in the synthesis of cardo polymers via nucleophilic substitution polymerization reaction.
- Asymmetric polyimides by a solution polycondensation reaction.
General Description
4-Fluorophthalic anhydride is a fluorinated building block commonly used in chemical synthesis for the preparation of polyimide, pesticides, herbicides, and fungicides. It can be synthesized by treating 4-chlorophthalic anhydride with potassium fluoride.
Properties of 5-Fluoro-1,3-isobenzofurandione
| Melting point: | 75-79 °C (lit.) |
| Boiling point: | 148°C 20mm |
| Density | 1.55 |
| Flash point: | >93°C |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in sodium hydroxide. |
| form | powder to crystal |
| color | White to Almost white |
| Sensitive | Moisture Sensitive |
| BRN | 131281 |
| CAS DataBase Reference | 319-03-9(CAS DataBase Reference) |
| EPA Substance Registry System | 1,3-Isobenzofurandione, 5-fluoro- (319-03-9) |
Safety information for 5-Fluoro-1,3-isobenzofurandione
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Fluoro-1,3-isobenzofurandione
| InChIKey | XVMKZAAFVWXIII-UHFFFAOYSA-N |
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