5-CYCLOHEXADECEN-1-ONE
- CAS NO.：37609-25-9
- Empirical Formula: C16H28O
- Molecular Weight: 236.39
- MDL number: MFCD00059511
- EINECS: 253-568-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:07:17
What is 5-CYCLOHEXADECEN-1-ONE?
Chemical properties
5-CYCLOHEXADECEN-1-ONE is commercially available as a
40 : 60 mixture of its (Z)- and (E)-isomers. It is a colorless liquid with an intense
musk odor.
A three-step synthesis starts from cyclododecanone. Reaction with chlorine
gives 2-chlorocyclododecanone, which is reacted with 2 mol of vinyl magnesium
chloride to give 1,2-divinylcyclododecan-l-ol. This is finally converted into
5-cyclohexadecen-1-one by an oxy-Cope rearrangement.
5-Cyclohexadecen-l-one can be added to perfume compositions as a substitute
for the natural macrocyclic ketone musks：
Trade name
Musk TM-II (Soda Aromatic), Velvione® (Givaudan), Ambretone® (Takasago)
Properties of 5-CYCLOHEXADECEN-1-ONE
| Melting point: | 25 °C |
| Boiling point: | 120 °C / 1mmHg |
| Density | 0.93 |
| vapor pressure | 0.02Pa at 20℃ |
| Flash point: | 166 °C |
| form | Liquid |
| color | White to Almost white |
| Odor | at 10.00 % in dipropylene glycol. dry powdery musk amber civet |
| EPA Substance Registry System | 5-Cyclohexadecen-1-one (37609-25-9) |
Safety information for 5-CYCLOHEXADECEN-1-ONE
Computed Descriptors for 5-CYCLOHEXADECEN-1-ONE
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