5-Chlorothiophene-2-sulfonyl chloride
- CAS NO.：2766-74-7
- Empirical Formula: C4H2Cl2O2S2
- Molecular Weight: 217.09
- MDL number: MFCD00051667
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:45:54
What is 5-Chlorothiophene-2-sulfonyl chloride?
Chemical properties
5-Chlorothiophene-2-sulfonyl chloride is white to yellow crystalline low melting solid
The Uses of 5-Chlorothiophene-2-sulfonyl chloride
5-Chlorothiophene-2-sulfonyl chloride is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs. It is used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.
The Uses of 5-Chlorothiophene-2-sulfonyl chloride
5-Chloro-2-thiophenesulfonyl Chloride is a sulfonylthiophene derivative used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.
Synthesis Reference(s)
Tetrahedron, 21, p. 1333, 1965 DOI: 10.1016/S0040-4020(01)98293-6
General Description
5-Chlorothiophene-2-sulfonyl chloride can be prepared from 2-chlorothiophene by reacting with chlorosulfonic acid in the presence of phosphorus pentachloride.
Properties of 5-Chlorothiophene-2-sulfonyl chloride
| Melting point: | 25-28°C |
| Boiling point: | 112-117 °C (lit.) |
| Density | 1.623 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| form | solid |
| color | Colorless to Yellow to Orange |
| Specific Gravity | 1.623 |
| Water Solubility | Not miscible in water. |
| Sensitive | Moisture Sensitive |
| BRN | 130710 |
| CAS DataBase Reference | 2766-74-7(CAS DataBase Reference) |
Safety information for 5-Chlorothiophene-2-sulfonyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 5-Chlorothiophene-2-sulfonyl chloride
| InChIKey | SORSTNOXGOXWAO-UHFFFAOYSA-N |
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